Module Title:Pharmaceutical Science
Language of Instruction:English
Credits: 5
NFQ Level:6
Module Delivered In 3 programme(s)
Teaching & Learning Strategies: This module will be taught in one theory classes of one hour duration plus one 3 hour practical per week for 15 weeks. To consolidate lectures and practicals, students will normally be required to carry out assignments and prepare a weekly practical report analysing their own research and results. Any course-related issue or questions that may arise will be discussed at lectures.
Module Aim: To analyse and assay pharmaceutical formulations using different analytical techniques
Learning Outcomes
On successful completion of this module the learner should be able to:
LO1 Operate analytical techniques used in the analysis of pharmaceuticals.
LO2 Carry out pharmaceutical assays and chromatographic separations of drugs
LO3 Identify certain categories of drugs.
LO4 Understand quality control measures in pharmaceutical analysis.
Pre-requisite learning
Module Recommendations

This is prior learning (or a practical skill) that is recommended before enrolment in this module.

No recommendations listed
Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module.
No incompatible modules listed
Co-requisite Modules
No Co-requisite modules listed
Requirements
This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed.
Successful completion of year 1 or equivalent
 

Module Content & Assessment

Indicative Content
Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. BP and USP monographs of pure drugs and formulations including assays, storage and identification
Pharmaceutical chemistry
Categories of pharmaceuticals. vitamins, analgesics. general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors and barbiturates.
Control of the quality of analytical method
Control of errors in analysis. repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness
Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
Analytical techniques
Analytical methods used in drug analysis – UV/Vis, FAAS, FES, Titrimetric, IR, methods. E(1%,1cm). Dissolution testing
Extraction methods in pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods.
Chromatographic Techniques
Use in the analysis of drugs. Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution selectivity. Gas liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary phases. Columns detectors solvents. Sample preparation. Qualitative and quantitative measurements. Internal standards.
Practical
Practicals will develop skills in the use of analytical equipment and techniques from AAS, FP, FTIR, HPLC, GC, UV-Vis in the analysis of selected pharmaceutical products. Specific assays from the BP will also be covered The use of updated software, e.g. EMPOWER for HPLC and PROBE for UV-Vis will be used also.
Assessment Breakdown%
Continuous Assessment10.00%
Practical40.00%
End of Module Formal Examination50.00%
Special Regulation
Students must achieve a minimum grade (35%) in both the practical/CA and final examination.
Continuous Assessment
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Examination Exam 1,2,3,4 5.00 n/a
Examination Exam 1,2,3,4 5.00 n/a
No Project
Practical
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Practical/Skills Evaluation Practical Log Book 1,2 40.00 Sem 1 End
End of Module Formal Examination
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Formal Exam 2 hour exam 1,2,3,4 50.00 End-of-Semester

ITCarlow reserves the right to alter the nature and timings of assessment

 

Module Workload

Workload: Full Time
Workload Type Frequency Average Weekly Learner Workload
Lecture 30 Weeks per Stage 1.00
Laboratory 30 Weeks per Stage 1.50
Estimated Learner Hours 30 Weeks per Stage 1.00
Total Hours 105.00
 

Module Delivered In

Programme Code Programme Semester Delivery
CW_SASES_B Bachelor of Science (Honours) in Environmental Science 2 Mandatory
CW_SAASC_D Bachelor of Science in Analytical Science 2 Mandatory
CW_SASCI_C Higher Certificate in Science in Applied Biology or Applied Chemistry 2 Group Elective 2