| Module Title: | Pharmaceutical Science |
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| Language of Instruction: | English |
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| Teaching & Learning Strategies: |
This module will be taught in two theory classes of 1 hour duration plus one 3 hour practical per week for 12 weeks. To consolidate lectures and practicals, students will normally be required to carry out assignments and prepare a weekly practical report analysing their own research and results. Any course-related issue or questions that may arise will be discussed at lectures. |
| Module Aim: |
To analyse and assay pharmaceutical formulations using different analytical techniques |
| Learning Outcomes |
| On successful completion of this module the learner should be able to: |
| LO1 |
To carry out chromatographic separations of drugs, pharmaceutical assays, and to operate analytical techniques used in the analysis of pharmaceuticals. |
| LO2 |
To identify certain categories of drugs. |
| LO3 |
Comprehend and apply quality control measures in pharmaceutical analysis. |
| Pre-requisite learning |
Module Recommendations
This is prior learning (or a practical skill) that is recommended before enrolment in this module.
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| No recommendations listed |
Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module. |
| No incompatible modules listed |
Co-requisite Modules
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| No Co-requisite modules listed |
Requirements
This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed. |
| Successful completion of year 1 or equivalent |
Module Content & Assessment
| Indicative Content |
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Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. European Pharmacoipoeia, BP and USP monographs of pure drugs and formulations including assays, storage and identification.
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Pharmaceutical chemistry
Selected categories of pharmaceuticals: vitamins, analgesics, general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors,
barbiturates.
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Control of the quality of analytical method
Control of errors in analysis. Repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness.
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Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
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Analytical techniques
Analytical methods used in drug analysis – UV/Vis, AAS, AES, Titrimetric,IR, GC and HPLC methods. E(1%,1cm). Dissolution testing
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Extraction methods in pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods.
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Chromatographic Techniques
Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution, selectivity. Gas-liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary phases. Columns, detectors, solvents. Use in the analysis of drugs. Sample preparation. Qualitative and quantitative measurements. Internal standards.
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Practical
Practicals will develop skills in the use of analytical equipment and techniques from AAS, AES, FTIR, HPLC, GC, UV-Vis in the analysis of selected pharmaceutical products. Specific assays from the BP or the EP will also be carried out.
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| Assessment Breakdown | % |
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| Continuous Assessment | 60.00% |
| Practical | 40.00% |
| Special Regulation |
| Students must achieve a minimum grade (35%) in both the practical and the CA. |
| Continuous Assessment |
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| Assessment Type |
Assessment Description |
Outcome addressed |
% of total |
Assessment Date |
| Examination |
Exam |
1,2,3 |
30.00 |
n/a |
| Examination |
Exam |
1,2,3 |
30.00 |
n/a |
| Practical |
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| Assessment Type |
Assessment Description |
Outcome addressed |
% of total |
Assessment Date |
| Practical/Skills Evaluation |
Lab Worksheets and Reports;
Practical Log Book |
1 |
40.00 |
n/a |
| No End of Module Formal Examination |
SETU Carlow Campus reserves the right to alter the nature and timings of assessment
Module Workload
| Workload: Full Time |
| Workload Type |
Frequency |
Average Weekly Learner Workload |
| Lecture |
12 Weeks per Stage |
2.00 |
| Laboratory |
12 Weeks per Stage |
3.00 |
| Estimated Learner Hours |
15 Weeks per Stage |
4.33 |
| Total Hours |
125.00 |
Module Delivered In
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