| Module Title: | Analytical Techniques Pharmaceutical Science |
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| Language of Instruction: | English |
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| Teaching & Learning Strategies: |
This module will be taught in four theory classes of 1 hour duration per week plus 16 x 3 hour labs delivered on a rota. Lectures will be linked to practical classes and the practical component will allow students to develop the required technical competencies, attitudes and behaviours, and promote good record keeping and timely submission of reports. |
| Module Aim: |
The aim of this module is to impart knowledge of basic analytical principles together with practical applications in pharmaceutical and related industries |
| Learning Outcomes |
| On successful completion of this module the learner should be able to: |
| LO1 |
Explain and demonstrate a range of analytical techniques and discussthe theoretical background on which they are based. |
| LO2 |
Operate analytical techniques used in the analysis of pharmaceuticals. |
| LO3 |
Comprehend and apply quality control measures in pharmaceutical analysis. |
| LO4 |
Carry out pharmaceutical assays and chromatographic separations of drugs. |
| LO5 |
Identify certain categories of drugs. |
| Pre-requisite learning |
Module Recommendations
This is prior learning (or a practical skill) that is recommended before enrolment in this module.
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| No recommendations listed |
Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module. |
| No incompatible modules listed |
Co-requisite Modules
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| No Co-requisite modules listed |
Requirements
This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed. |
| Successful completion of year 1 or equivalent |
Module Content & Assessment
| Indicative Content |
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Analytical Techniques and Procedures
General approach to analytical procedures. Steps in analytical analysis. Representative sampling, sample preparation, analysis and interpretation of results. Systematic error and random error. Precision and accuracy. Measurement uncertainty.
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Titrimetric Methods:
Review of concentration calculations, ppm, w/w,w/v dilutions of solutions. Principles of titrations
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Spectroscopic Methods
Properties of light. Electromagnetic spectrum. Absorption of light. Beers Law. Absorption Spectra and colour. Spectrometer - good operating techniques. Applications of Beers' Law. Principles of atomic absorption and flame emission spectroscopy, sample treatment, use of standards. Interferences standard addition methods applications. Infra-red spectroscopy. Sample preparation. Identification of compounds using correlation charts
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Separation and Chromatographic Techniques
Separation and Chromatographic Techniques: Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution selectivity. Gas-liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary places. Columns detectors solvents. Sample preparation. Qualitative and quantitative measurements. Use in the analysis of drugs. Internal standards. Ion chromatography. Solvent extraction
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The Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. European Pharmacoipoeia, BP and USP monographs of pure drugs and formulations including assays, storage and identification.
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Pharmaceutical Chemistry
Selected categories of pharmaceuticals: vitamins, analgesics, general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors, barbiturates.
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Analytical Techniques
Analytical methods used in drug analysis – UV/Vis, AAS, AES, Titrimetric, IR, GC and HPLC methods. E(1%,1cm). Dissolution testing.
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Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
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Extraction Methods in Pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods
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Control of the quality of analytical methods
Control of errors in analysis. Repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness.
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Practical
Practicals will develop skills in the use of analytical equipment and techniques from AAS, AES, FTIR, HPLC, GC, and UV-Vis and ion chromatography. The practicals covered will reinforce and amplify the material covered in the lecture course. The use of updated software will be implemented.
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| Assessment Breakdown | % |
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| Continuous Assessment | 60.00% |
| Practical | 40.00% |
| Special Regulation |
| Students must achieve a minimum grade (35%) in both the practical and CA |
| Continuous Assessment |
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| Assessment Type |
Assessment Description |
Outcome addressed |
% of total |
Assessment Date |
| Examination |
written assessment examination |
1,5 |
20.00 |
n/a |
| Examination |
written assessment examination. |
1,5 |
20.00 |
n/a |
| Examination |
written assessment examination |
1,5 |
20.00 |
n/a |
| Practical |
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| Assessment Type |
Assessment Description |
Outcome addressed |
% of total |
Assessment Date |
| Practical/Skills Evaluation |
Laboratory worksheets and reports
Practical Log Book |
2,3,4 |
40.00 |
n/a |
| No End of Module Formal Examination |
SETU Carlow Campus reserves the right to alter the nature and timings of assessment
Module Workload
| Workload: Full Time |
| Workload Type |
Frequency |
Average Weekly Learner Workload |
| Lecture |
12 Weeks per Stage |
4.00 |
| Laboratory |
12 Weeks per Stage |
4.00 |
| Estimated Learner Hours |
15 Weeks per Stage |
10.27 |
| Total Hours |
250.00 |
Module Delivered In
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