Module Title:Analytical Techniques Pharmaceutical Science
Language of Instruction:English
Credits: 10
NFQ Level:6
Module Delivered In 3 programme(s)
Teaching & Learning Strategies: This module will be taught in four theory classes of 1 hour duration per week plus 16 x 3 hour labs delivered on a rota. Lectures will be linked to practical classes and the practical component will allow students to develop the required technical competencies, attitudes and behaviours, and promote good record keeping and timely submission of reports.
Module Aim: The aim of this module is to impart knowledge of basic analytical principles together with practical applications in pharmaceutical and related industries
Learning Outcomes
On successful completion of this module the learner should be able to:
LO1 Explain and demonstrate a range of analytical techniques and discussthe theoretical background on which they are based.
LO2 Operate analytical techniques used in the analysis of pharmaceuticals.
LO3 Comprehend and apply quality control measures in pharmaceutical analysis.
LO4 Carry out pharmaceutical assays and chromatographic separations of drugs.
LO5 Identify certain categories of drugs.
Pre-requisite learning
Module Recommendations

This is prior learning (or a practical skill) that is recommended before enrolment in this module.

No recommendations listed
Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module.
No incompatible modules listed
Co-requisite Modules
No Co-requisite modules listed
This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed.
Successful completion of year 1 or equivalent

Module Content & Assessment

Indicative Content
Analytical Techniques and Procedures
General approach to analytical procedures. Steps in analytical analysis. Representative sampling, sample preparation, analysis and interpretation of results. Systematic error and random error. Precision and accuracy. Measurement uncertainty.
Titrimetric Methods:
Review of concentration calculations, ppm, w/w,w/v dilutions of solutions. Principles of titrations
Spectroscopic Methods
Properties of light. Electromagnetic spectrum. Absorption of light. Beers Law. Absorption Spectra and colour. Spectrometer - good operating techniques. Applications of Beers' Law. Principles of atomic absorption and flame emission spectroscopy, sample treatment, use of standards. Interferences standard addition methods applications. Infra-red spectroscopy. Sample preparation. Identification of compounds using correlation charts
Separation and Chromatographic Techniques
Separation and Chromatographic Techniques: Principles of adsorption, partition, ion exchange, molecular and affinity chromatography. Chromatogram description. Theoretical plates. Resolution selectivity. Gas-liquid chromatography. High performance liquid chromatography. Methods of separation. Mobile and stationary places. Columns detectors solvents. Sample preparation. Qualitative and quantitative measurements. Use in the analysis of drugs. Internal standards. Ion chromatography. Solvent extraction
The Pharmaceutical industry
Introduction to pharmaceutical industry. Primary and secondary manufacture. Basic calculations in pharmaceutical analysis. Licensing of drugs and the pharmacopoeia. European Pharmacoipoeia, BP and USP monographs of pure drugs and formulations including assays, storage and identification.
Pharmaceutical Chemistry
Selected categories of pharmaceuticals: vitamins, analgesics, general and local anaesthetics, sulphonamides antibiotics, antacids and acid-inhibitors, barbiturates.
Analytical Techniques
Analytical methods used in drug analysis – UV/Vis, AAS, AES, Titrimetric, IR, GC and HPLC methods. E(1%,1cm). Dissolution testing.
Chemistry of acids and bases
Ionisation of drugs. pKa values of drugs. Partition coefficients relating to drug absorption.
Extraction Methods in Pharmaceutical analysis
Excipients in formulations. Solvent and solid phase extraction methods
Control of the quality of analytical methods
Control of errors in analysis. Repeatability and reproducibility. Validation of drug analysis to include assay, precision specificity, LOD, LOQ, linearity, ruggedness and robustness.
Practicals will develop skills in the use of analytical equipment and techniques from AAS, AES, FTIR, HPLC, GC, and UV-Vis and ion chromatography. The practicals covered will reinforce and amplify the material covered in the lecture course. The use of updated software will be implemented.
Assessment Breakdown%
Continuous Assessment60.00%
Special Regulation
Students must achieve a minimum grade (35%) in both the practical and CA
Continuous Assessment
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Examination written assessment examination 1,5 20.00 n/a
Examination written assessment examination. 1,5 20.00 n/a
Examination written assessment examination 1,5 20.00 n/a
No Project
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Practical/Skills Evaluation Laboratory worksheets and reports Practical Log Book 2,3,4 40.00 n/a
No End of Module Formal Examination

SETU Carlow Campus reserves the right to alter the nature and timings of assessment


Module Workload

Workload: Full Time
Workload Type Frequency Average Weekly Learner Workload
Lecture 12 Weeks per Stage 4.00
Laboratory 12 Weeks per Stage 4.00
Estimated Learner Hours 15 Weeks per Stage 10.27
Total Hours 250.00

Module Delivered In

Programme Code Programme Semester Delivery
CW_SABTP_B Bachelor of Science (Honours) in Biosciences with Biopharmaceuticals 4 Mandatory
CW_SABFQ_D Bachelor of Science in Biosciences 4 Mandatory
CW_SASCI_C Higher Certificate in Science in Applied Biology or Applied Chemistry 4 Group Elective 1